Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure. (2023)

Background-Fish oil reduces sudden death in patients with prior myocardial infarction. Sudden death in heart failure may be due to triggered activity based on disturbed calcium handling. We hypothesized that superfusion with ω3-polyunsaturated fatty acids (ω3-PUFAs) from fish inhibits triggered activity in heart failure. Methods and Results-Ventricular myocytes were isolated from explanted hearts of rabbits with volume- and pressure-overload-induced heart failure and of patients with end-stage heart failure. Membrane potentials (patch-clamp technique) and intracellular calcium (indo-1 fluorescence) were recorded after 5 minutes of superfusion with Tyrode's solution (control), ω-9 monounsaturated fatty acid oleic acid (20 μmol/L), or ω3-PUFAs (docosahexaenoic acid or eicosapentaenoic acid 20 μmol/L). ω3-PUFAs shortened the action potential at low stimulation frequencies and caused an ≈25% decrease in diastolic and systolic calcium (all P<0.05). Subsequently, noradrenalin and rapid pacing were used to evoke triggered activity, delayed afterdepolarizations, and calcium aftertransients. ω3-PUFAs abolished triggered activity and reduced the number of delayed afterdepolarizations and calcium aftertransients compared with control and oleic acid. ω3-PUFAs reduced action potential shortening and intracellular calcium elevation in response to noradrenalin. Results from human myocytes were in accordance with the findings obtained in rabbit myocytes. Conclusion-Superfusion with ω3-PUFAs from fish inhibits triggered arrhythmias in myocytes from rabbits and patients with heart failure by lowering intracellular calcium and reducing the response to noradrenalin. (Circulation. 2008;117: 536-544.). © 2008 American Heart Association, Inc.

Original languageEnglish
Pages (from-to)536-544
Number of pages10
JournalCirculation
Volume117
Issue number4
DOIs
Publication statusPublished - 2008
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den Ruijter, H. M., Berecki, G., Verkerk, A. O., Bakker, D., Baartscheer, A., Schumacher, C. A., Belterman, C. N., de Jonge, N., Fiolet, J. W., Brouwer, I. A., & Coronel, R. (2008). Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure. Circulation, 117(4), 536-544. https://doi.org/10.1161/CIRCULATIONAHA.107.733329

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den Ruijter, H.M. ; Berecki, G. ; Verkerk, A.O. ; Bakker, D. ; Baartscheer, A. ; Schumacher, C.A. ; Belterman, C.N. ; de Jonge, N. ; Fiolet, J.W. ; Brouwer, I.A. ; Coronel, R. / Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure. In: Circulation. 2008 ; Vol. 117, No. 4. pp. 536-544.

@article{6eb5736feab64769b68bccdb6e3b18a5,

title = "Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.",

abstract = "Background-Fish oil reduces sudden death in patients with prior myocardial infarction. Sudden death in heart failure may be due to triggered activity based on disturbed calcium handling. We hypothesized that superfusion with ω3-polyunsaturated fatty acids (ω3-PUFAs) from fish inhibits triggered activity in heart failure. Methods and Results-Ventricular myocytes were isolated from explanted hearts of rabbits with volume- and pressure-overload-induced heart failure and of patients with end-stage heart failure. Membrane potentials (patch-clamp technique) and intracellular calcium (indo-1 fluorescence) were recorded after 5 minutes of superfusion with Tyrode's solution (control), ω-9 monounsaturated fatty acid oleic acid (20 μmol/L), or ω3-PUFAs (docosahexaenoic acid or eicosapentaenoic acid 20 μmol/L). ω3-PUFAs shortened the action potential at low stimulation frequencies and caused an ≈25% decrease in diastolic and systolic calcium (all P<0.05). Subsequently, noradrenalin and rapid pacing were used to evoke triggered activity, delayed afterdepolarizations, and calcium aftertransients. ω3-PUFAs abolished triggered activity and reduced the number of delayed afterdepolarizations and calcium aftertransients compared with control and oleic acid. ω3-PUFAs reduced action potential shortening and intracellular calcium elevation in response to noradrenalin. Results from human myocytes were in accordance with the findings obtained in rabbit myocytes. Conclusion-Superfusion with ω3-PUFAs from fish inhibits triggered arrhythmias in myocytes from rabbits and patients with heart failure by lowering intracellular calcium and reducing the response to noradrenalin. (Circulation. 2008;117: 536-544.). {\textcopyright} 2008 American Heart Association, Inc.",

author = "{den Ruijter}, H.M. and G. Berecki and A.O. Verkerk and D. Bakker and A. Baartscheer and C.A. Schumacher and C.N. Belterman and {de Jonge}, N. and J.W. Fiolet and I.A. Brouwer and R. Coronel",

year = "2008",

doi = "10.1161/CIRCULATIONAHA.107.733329",

language = "English",

volume = "117",

pages = "536--544",

journal = "Circulation",

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issn = "0009-7322",

publisher = "American Heart Association",

number = "4",

}

den Ruijter, HM, Berecki, G, Verkerk, AO, Bakker, D, Baartscheer, A, Schumacher, CA, Belterman, CN, de Jonge, N, Fiolet, JW, Brouwer, IA & Coronel, R 2008, 'Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.', Circulation, vol. 117, no. 4, pp. 536-544. https://doi.org/10.1161/CIRCULATIONAHA.107.733329

Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure. / den Ruijter, H.M.; Berecki, G.; Verkerk, A.O.; Bakker, D.; Baartscheer, A.; Schumacher, C.A.; Belterman, C.N.; de Jonge, N.; Fiolet, J.W.; Brouwer, I.A.; Coronel, R.

In: Circulation, Vol. 117, No. 4, 2008, p. 536-544.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

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T1 - Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure.

AU - den Ruijter, H.M.

AU - Berecki, G.

AU - Verkerk, A.O.

AU - Bakker, D.

AU - Baartscheer, A.

AU - Schumacher, C.A.

AU - Belterman, C.N.

AU - de Jonge, N.

AU - Fiolet, J.W.

AU - Brouwer, I.A.

AU - Coronel, R.

PY - 2008

Y1 - 2008

N2 - Background-Fish oil reduces sudden death in patients with prior myocardial infarction. Sudden death in heart failure may be due to triggered activity based on disturbed calcium handling. We hypothesized that superfusion with ω3-polyunsaturated fatty acids (ω3-PUFAs) from fish inhibits triggered activity in heart failure. Methods and Results-Ventricular myocytes were isolated from explanted hearts of rabbits with volume- and pressure-overload-induced heart failure and of patients with end-stage heart failure. Membrane potentials (patch-clamp technique) and intracellular calcium (indo-1 fluorescence) were recorded after 5 minutes of superfusion with Tyrode's solution (control), ω-9 monounsaturated fatty acid oleic acid (20 μmol/L), or ω3-PUFAs (docosahexaenoic acid or eicosapentaenoic acid 20 μmol/L). ω3-PUFAs shortened the action potential at low stimulation frequencies and caused an ≈25% decrease in diastolic and systolic calcium (all P<0.05). Subsequently, noradrenalin and rapid pacing were used to evoke triggered activity, delayed afterdepolarizations, and calcium aftertransients. ω3-PUFAs abolished triggered activity and reduced the number of delayed afterdepolarizations and calcium aftertransients compared with control and oleic acid. ω3-PUFAs reduced action potential shortening and intracellular calcium elevation in response to noradrenalin. Results from human myocytes were in accordance with the findings obtained in rabbit myocytes. Conclusion-Superfusion with ω3-PUFAs from fish inhibits triggered arrhythmias in myocytes from rabbits and patients with heart failure by lowering intracellular calcium and reducing the response to noradrenalin. (Circulation. 2008;117: 536-544.). © 2008 American Heart Association, Inc.

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AB - Background-Fish oil reduces sudden death in patients with prior myocardial infarction. Sudden death in heart failure may be due to triggered activity based on disturbed calcium handling. We hypothesized that superfusion with ω3-polyunsaturated fatty acids (ω3-PUFAs) from fish inhibits triggered activity in heart failure. Methods and Results-Ventricular myocytes were isolated from explanted hearts of rabbits with volume- and pressure-overload-induced heart failure and of patients with end-stage heart failure. Membrane potentials (patch-clamp technique) and intracellular calcium (indo-1 fluorescence) were recorded after 5 minutes of superfusion with Tyrode's solution (control), ω-9 monounsaturated fatty acid oleic acid (20 μmol/L), or ω3-PUFAs (docosahexaenoic acid or eicosapentaenoic acid 20 μmol/L). ω3-PUFAs shortened the action potential at low stimulation frequencies and caused an ≈25% decrease in diastolic and systolic calcium (all P<0.05). Subsequently, noradrenalin and rapid pacing were used to evoke triggered activity, delayed afterdepolarizations, and calcium aftertransients. ω3-PUFAs abolished triggered activity and reduced the number of delayed afterdepolarizations and calcium aftertransients compared with control and oleic acid. ω3-PUFAs reduced action potential shortening and intracellular calcium elevation in response to noradrenalin. Results from human myocytes were in accordance with the findings obtained in rabbit myocytes. Conclusion-Superfusion with ω3-PUFAs from fish inhibits triggered arrhythmias in myocytes from rabbits and patients with heart failure by lowering intracellular calcium and reducing the response to noradrenalin. (Circulation. 2008;117: 536-544.). © 2008 American Heart Association, Inc.

U2 - 10.1161/CIRCULATIONAHA.107.733329

DO - 10.1161/CIRCULATIONAHA.107.733329

M3 - Article

VL - 117

SP - 536

EP - 544

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 4

ER -

den Ruijter HM, Berecki G, Verkerk AO, Bakker D, Baartscheer A, Schumacher CA et al. Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure. Circulation. 2008;117(4):536-544. https://doi.org/10.1161/CIRCULATIONAHA.107.733329

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FAQs

How important is fish oil for heart health? ›

The benefits of fish oil for heart health include: Improved cholesterol levels. It can increase levels of HDL (good) cholesterol and may also lower levels of LDL (bad) cholesterol ( 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ).

How does fish oil reduce inflammation? ›

How does it work? Fish oils are rich in omega-3 essential fatty acids, which have strong anti-inflammatory properties: They significantly reduce the release of several elements that play a part in inflammation from your white blood cells.

Can fish oil cause arrhythmias? ›

Smidt Heart Institute researchers have found that taking high doses of fish oil supplements—specifically one gram or more per day—may increase the risk of developing atrial fibrillation, an abnormal heart rhythm disturbance with potentially serious complications.

Can omega-3 cause arrhythmias? ›

Some clinical trials have suggested that omega-3 fatty acids may be associated with an increased risk for atrial fibrillation, the most common heart rhythm disorder. People with the disorder have a five times greater likelihood of having a stroke.

Does fish oil reduce risk of heart disease? ›

Omega-3 polyunsaturated fatty acids (PUFAs) found in fish oil have been reported to reduce the risk of cardiovascular disease, primarily eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), which have been the most widely available and most studied.

Can fish oil stop heart attacks? ›

Omega-3s from fish and fish oil have been recommended by the American Heart Association (AHA) for the past 20 years to reduce cardiovascular events, like heart attack or stroke, in people who already have cardiovascular disease (CVD).

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